I am a huge fan of Naya Rivera. All my sets will be based around her in some way, whether it's fashion, art, Glee, Real Life or else.
Santana Lopez is my favorite female character on TV, but since I am not lesbian myself, I won't ALWAYS pair her strictly with Brittany, or Quinn or females in general. I will pair her with men to, even though I know that Santana Lopez is, in fact, a lesbian. I honestly have little to no regard when it comes to on-screen ships and their character's sexual orientation.
But I do happen like Brittana, Quinntana and Pezberry, though, and will do sets around them, too - friendship-based and romantic.
I also happen to love True Blood, Supernatural and Sons of Anarchy - Alexander Skarsgard, Joe Manganiello, Jensen Ackles and Charlie Hunnam are just too hot for words. I will pair them up with Naya Rivera at least once. If not romantically, then some other way. So expect this to happen at some point (and probably more than once). Other men too!